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Download e-book for kindle: A textbook of modern toxicology by Ernest Hodgson

By Ernest Hodgson

ISBN-10: 047046206X

ISBN-13: 9780470462065

A Textbook of contemporary Toxicology is a different source that gives either scholars and practitioners with a wide-ranging, obtainable evaluate of the self-discipline. appropriate for classes in environmental, pharmacological, clinical, and veterinary toxicology, this crucial textual content positive factors chapters written via specialists who deal with more than a few key topics.The Fourth variation contains extra chapters on new methods to toxicology - molecular equipment (-omics: toxicogenomics, proteomics, and metabolomics), bioinformatics, and structures biology – and maintains the legacy of its predecessors to supply updated insights into acute toxicity and chemical carcinogenesis, organ toxicity, in vitro and in vivo toxicity trying out, ecological hazard evaluation, and plenty of different components of toxicology that support foster a fantastic comprehension of the field.Also featured within the Fourth variation are end-of-chapter questions and a options guide on hand individually for tutorial adopters.

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With the publication of her controversial book, The Silent Spring, in 1962, Rachel Carson became an important influence in initiating the modern era of environmental toxicology. Her book emphasized stopping the widespread, indiscriminate use of pesticides and other chemicals and advocated use patterns based on sound ecology. S. EPA and she is regarded by many as the mother of the environmental movement. It is clear, however, that since the 1960s, toxicology has entered a phase of rapid development and has changed from a science that was largely descriptive to one in which the importance of mechanisms of toxic action is generally recognized.

Chemical Use Classes. This includes the toxicology aspects of the development of new chemicals for commercial use. In some of these use classes, toxicity, at least to some organisms, is a desirable trait; in others, it is an undesirable side effect. Use classes are not composed entirely of synthetic chemicals; many natural products are isolated and are used for commercial and other purposes and must be subjected to the same toxicity testing as that required for synthetic chemicals. Examples of such natural products include the insecticide, pyrethrin, the clinical drug, digitalis, and the drug of abuse, cocaine.

It covers the gamut from short-term tests for genotoxicity such as the Ames test and cell culture techniques to the use of intact animals for a variety of tests from acute toxicity to lifetime chronic toxicity. Although the term “bioassay” is used properly only to describe the use of a living organism to quantitate the amount of a particular toxicant present, it is frequently used to describe any in vivo toxicity test. 6. Toxicologic pathology is that branch of pathology that deals with the effects of toxic agents manifested as changes in subcellular, cellular, tissue, or organ morphology.

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A textbook of modern toxicology by Ernest Hodgson

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