By Judah Folkman (auth.), William D. Figg, Judah Folkman (eds.)
Dr. Judah Folkman, “father of angiogenesis”, (1933-2008) used to be the Director of the Vascular Biology software, Andrus Professor of Pediatric surgical procedure, and Professor of phone Biology at Harvard University's Boston kid's health facility. within the 1971 factor of the hot England magazine of medication, he proposed the speculation that tumor development is angiogenesis based. This premise was once the foundation of this box of study and has turn into the point of interest of scientists world wide. due to Folkman's discovery and study, the probabilities of antiangiogenic and angiogenic remedy have broadened past melanoma to many noncancerous diseases.
This ebook represents the 1st assortment in a quantity of which Dr. Folkman is co-editor. Dr. Folkman authored approximately four hundred unique papers and greater than a hundred booklet chapters.
Dr. William Figg is the executive of the Molecular and scientific Pharmacology application on the nationwide melanoma Institute, nationwide Institutes of wellbeing and fitness. over the last 15 years, his laboratory and health center on the NCI have all for the advance of angiogenesis inhibitors. Dr. Figg has released greater than 380 publications.
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Additional info for Angiogenesis: An Integrative Approach From Science to Medicine
Treatment with AG-013736 reduces by about one-third the population of α-SMA-positive pericytes in RIP-Tag2 tumors [46, 49]. This reduction reverses rapidly and is fully back to baseline within 4 days after the treatment ends. PDGFR-β immunoreactivity does not undergo a corresponding reduction during treatment, suggesting that AG-013736 induces a reversible change in pericyte phenotype, characterized by reduction in α-SMA expression, rather than a decrease in number of pericytes. AG-028262, a potent small molecule inhibitor of VEGFR-2 phosphorylation with little action on PDGFR-β, has similar effects on α-SMA expression .
89. Brem S, Brem H, Folkman J, Finkelstein D, Patz A. Prolonged tumor dormancy by prevention of neovascularization in the vitreous. Canc Res 1976; 36:2807. 90. Brouty-Boye D, Zetter B. Inhibition of cell motility by interferon. Science 1980; 208: 516. 91. Dvorak HF, Gresser I. Microvascular injury in pathogenesis of interferon-induced necrosis of subcutaneous tumors in mice. J Natl Cancer Inst 1989; 81:497. 92. White CW, Sondheimer HM, Crouch EC, Wilson H, Fan LL. Treatment of pulmonary hemangiomatosis with recombinant interferon alfa-2a.
The model of experimental M. pulmonis infection makes it possible to examine the mechanism, consequences, and reversibility of angiogenesis and vascular remodeling in sustained inflammation. The overall architecture of the tracheal vasculature changes dramatically after M. pulmonis infection. The magnitude of 2. Angiogenesis and Vascular Remodeling in Inflammation and Cancer 19 Fig. 1A–D. Light micrograph (A) and corresponding drawing (B) of vasculature of rat tracheal mucosa after injection of particulate blue tracer, Monastral blue, and leak-inducing substance P (5 µg/kg iv) followed 3 min later by removal of intravascular tracer by vascular perfusion of fixative and staining of endothelial cells in situ with silver nitrate (from ).
Angiogenesis: An Integrative Approach From Science to Medicine by Judah Folkman (auth.), William D. Figg, Judah Folkman (eds.)