By Eleazar Shafrir, Anders A F Sima
Animal versions of Diabetes: A Primer introduces features of the main regularly occurring animal species with a variety of diabetic syndromes that have been constructed and broadly investigated over the last few many years. It comprises animal types which are available, good defined and confirmed to be of worth within the examine of either kinds of diabetes. greatly referenced, this booklet might be of price to new and proven investigators, graduate scholars and pharmaceutical scientists engaged on the improvement of antidiabetic and preventative modalities in a number of components of diabetes and its problems.
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Additional resources for Animal Models in Diabetes: A Primer (Frontiers in Animal Diabetes Research)
2 protein. Each allele of RT6 segregates as an autosomal dominant with variable penetrance. , 1993). MORDES ET AL. , 1996). As a result, a new nomenclature has been proposed (Haag and Koch-Nolte, 1997). For the rat, ART2a and ART2b will replace RT6a and RT6b, respectively. 2, respectively. , 1999). Cell biological studies of RT6 together with newer biochemical and molecular analyses suggest at least four potential mechanisms by which cells expressing RT6 could modulate immune reactivity. The simplest hypothesis is that RT6 merely marks T cells that regulate immune system activity indirectly.
O. (1989) Molecular characterization of MHC class II antigens (beta 1 domain) in the BB diabetes-prone and -resistant rat. Immunogenetics, 29, 231–234. , Kunakorn, T. A. (1995) Glimepirideinduced prevention of diabetes and autoimmune events in the BB rat: Revised. , 57, 2281–2290. D. H. NON-Thy-1a donors. Diabetes, 42, 44–55. , et al. (1997) Role of macrophages and macrophage-derived cytokines in the pathogenesis of Kilham rat virus-induced autoimmune diabetes in diabetesresistant BioBreeding rats.
1992) Increased vascular permeability in pancreas of diabetic rats: Detection with high resolution protein A-gold cytochemistry. Diabetologia, 35, 1118–24. A. P. (1990) Morphological and physiological characteristics of pancreas-specific venular permeability induced by Monastral blue B. Exp. Mol. , 52, 141–153. L. S. (1996) Autoantibodies to IA-2 not detected in NOD mice or BB rats. Diabetologia, 39, 1237–1238. , et al. (1996) Synergistic effect of deoxyspergualin (DSP) and cyclosporin A (CsA) in the prevention of spontaneous autoimmune diabetes in BB rats.
Animal Models in Diabetes: A Primer (Frontiers in Animal Diabetes Research) by Eleazar Shafrir, Anders A F Sima